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KMID : 1011320190110010048
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Journal of Pharmacoepidemiology and Risk Management
2019 Volume.11 No. 1 p.48 ~ p.51
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Oxaliplatin-induced Optic Neuritis: A Case Report
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Han Hye-Jin
Moon Mi-Ra
Kang Dong-Yoon
Kang Hye-Ryun
Lee Ju-Yeun
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Abstract
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Optic neuritis is a disease that occurred by inflammation in optic nerve and characterized by blurred vision, decreased visual field, dyschromatopsia, and pain on eye movement. Platinum compounds are known to cause a variety of ocular side effects and oxaliplatin induced ocular toxicity has been reported. A 70-year-old woman with colon cancer stage 3 reported abnormal pupillary response to the bright light and vision loss in both eyes starting two days after receiving 5th cycle of chemotherapy with oxaliplatin and capecitabine. After diagnostic test, she was diagnosed with oxaliplatin induced optic neuritis. The symptoms of visual disorder were recovered after starting intravenous steroid pulse therapy and chemotherapy discontinuation. Afterward capecitabine was resolved without recurring symptom. Clinicians should consider oxaliplatin as one of the culprit agents of optic neuritis when it occurred during chemotherapy.
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KEYWORD
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Oxaliplatin, Optic neuritis, Antineoplastic agents, Steroids
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